ダウンロード数 : ?
ファイル
言語
英語
属性
Original article
著者
Kagohashi, Yukiko
直良 博之
内容記述(抄録等)
Some biological response modifiers (BRMs) have been shown to suppress teratogenesis. We previously showed that PSK, a BRM and a protein-bound polysaccharide extracted from Basidiomycetes, suppressed X-irradiation-induced ocular anomalies in mouse embryos.
In those studies, we noticed that the irradiated and PSK-treated embryos tended to be smaller in body size than the controls that were irradiated but not treated with PSK, in spite of the reduced teratogenesis. In this study, therefore, we analyzed in detail systemic development from embryonic day (E)7.75 to E9.0 of embryos that were irradiated and treated with PSK at E7.5, following the same experimental protocol used in the previous study. PSK treatment not only enhanced the X-irradiationinduced developmental delay, but also delayed development, albeit less extensively, as compared with controls. These developmentally delayed embryos generally showed proportional and symmetric size reduction. Possible mechanisms of the PSK-induced delay in systemic development and a relation with its anti-teratogenic effect are discussed.
掲載誌名
Shimane journal of medical science
20
2
開始ページ
25
終了ページ
29
ISSN
03865959
ISSN(Online)
24332410
発行日
2002-12-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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