ダウンロード数 : ?
ファイル
言語
英語
著者
Kurioka, Soichi
内容記述(抄録等)
Objective: To clarify the relationship between serum hyaluronan levels and vascular function in type 2 diabetic patients.
Methods: A cross-sectional cohort study.
Results: In multivariate regression analysis, endothelium-dependent flow-mediated dilation was associated with age and duration of diabetes, but not with serum hyaluronan level, while endothelium-independent nitroglycerine-mediated dilation (NMD) was only associated with serum hyaluronan level (standardized estimate = -0.401, p = 0.003). NMD in the lowest tertile of hyaluronan level was significantly higher than the other tertiles (15.9% versus 12.5% and 10.4%, p = 0.047 and p = 0.002, respectively).
Conclusions: Serum hyaluronan level may be useful as a surrogate marker for early changes in the vascular function, which often occurs in patients with diabetes mellitus.
主題
Diabetes
hyaluronan
vascular function
掲載誌名
Biomarkers
19
6
開始ページ
493
終了ページ
497
ISSN
1354750X
発行日
2014-09
DOI
DOI公開日
2017-03-23
PubMed ID
NCID
AA11091761
出版者
Taylor & Francis
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in "Biomarkers" on 2014-09, available online: http://www.tandfonline.com/10.3109/1354750X.2014.940502.
著者版/出版社版
著者版
業績ID
e26993
e27254
e27336
部局
医学部
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