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ファイル
言語
英語
著者
Yamaguchi, Shuhei
内容記述(抄録等)
Research indicates that a subtle cognitive decline, accompanied by pathological changes, occurs in individuals with subjective memory complaints (SMC). However, there is less evidence regarding the measurement of resting-state functional connectivity to detect subtle brain network alterations in neurodegenerative illnesses before cognitive change manifestation. We investigated the correlation between SMC and cognitive performance and explored functional and structural brain changes underlying SMC severity, using behavioral and brain imaging data-driven approaches. We observed that SMC was associated with depression but not with cognitive test scores, implying that SMC represent the “worried-well”; however, this model explains only 15% of the target variance. Using a conservative threshold, we observed connectivity related to SMC severity in the lingual gyrus, cuneus, anterior insula, and superior parietal lobule. Post-hoc analysis indicated that occipital and parietal functional connectivity increased with SMC severity. In contrast, volumetric alterations were not associated with SMC, even after applying a liberal threshold. Our findings suggest that altered resting-state functional connectivity in regions associated with SMC might reflect early compensatory changes that occur before cognitive and structural abnormalities develop.
主題
Aging
Subjective memory complaints
Resting-state fMRI
Voxel-based morphometry
Depression
掲載誌名
NeuroImage. Clinical
2019
19
発行日
2019-01-11
DOI
PubMed ID
出版者
Elsevier
資料タイプ
学術雑誌論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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