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ファイル
言語
英語
属性
Review
著者
内容記述(抄録等)
Mesenchymal stem cells (MSCs) have many function, including immunomodulatory activity, tissuerepair capability and regeneration of bone, cartilage and fatty tisssues. MSC culture methods have been established, and safety can be ensured, so MSCs have been applied clinically to treatment of numerous diseases. With respect to hematological diseases, MSC treatment is expected to be effective for therapy-resistant acute graft-versus-host disease (GVHD). In addition, MSCs have been applied to areas such as treatment of chronic GVHD, prevention of GVHD, promotion of hematopoietic stem cell engraftment, and treatment of refractory aplastic anemia. However, on the basis of the cellular characteristics of MSCs, the potential for problems such as increase in relapse, exacerbation of infection, and cancer development must be borne in mind. This article review the current status of, issues with clinical applications to hematological diseases of MSCs.
主題
mesenchymal stem cell
hematological disease
graft versus host disease
掲載誌名
Shimane Journal of Medical Science
36
1
開始ページ
1
終了ページ
10
ISSN
03865959
ISSN(Online)
24332410
発行日
2019-06
NCID
AA00841586
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
部局
医学部
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