ID 38529
ファイル
言語
英語
著者
安田 英彰
川向 哲也
Utani, Etsuko
Tsuji, Seiichi
内容記述(抄録等)
Previous studies have demonstrated the autonomic dysregulation in patients with schizophrenia using electrophysiological methods, such as electrodermal measures and heart rate analysis. Several theories have been proposed to explain the underlying mechanisms of schizophrenia and its autonomic function. Recently, the measurement of salivary alpha-amylase has been considered to be a useful tool for evaluating the sympathetic-adrenal-medullary (SAM) system. Psychosocial stress increases the release of salivary alpha-amylase. Although some studies have evaluated salivary alpha-amylase under psychosocial stress, no studies have demonstrated the change in the salivary alpha-amylase (sAA) activity level in schizophrenic patients. We examined the relationship between sAA level and psychiatric state in patients with schizophrenia (n = 54) using a portable and rapid hand-held monitor to investigate sAA. The sAA activity in the patients was significantly higher than that in the control subjects (n = 55) (p < 0.01). The correlation between amylase level and psychiatric symptoms was highly significant (r = 0.37, p < 0.01). These findings indicate that higher increases in sAA may indicate severe psychiatric symptoms. These results indicate a predominant role of the sympathetic nervous system in the secretion of sAA, together with parasympathetic withdrawal, under psychosocial stress.
主題
Autonomic function
Psychological stress
Salivary alpha-amylase
Schizophrenia
Sympathetic-adrenal-medullary system
掲載誌名
Progress in neuro-psychopharmacology & biological psychiatry
34
4
開始ページ
688
終了ページ
691
ISSN
02785846
発行日
2010-05-30
DOI
DOI公開日
2017-03-08
PubMed ID
NCID
AA10532839
出版者
Elsevier
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© 2010 Elsevier Inc. All rights reserved.
著者版/出版社版
著者版
部局
教育学部
医学部