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language
eng
Attribute
Original article
Author
HOSSAIN, Kazi Helal
JAHAN, Israt
Nibayashi, Tomomi
Description
Although infection of Porphyromonas gingivalis (P. gingivalis) is closely correlated with progress of vascular inflammatory diseases, distinctive pathogenesis induced by P. gingivalis is still elusive. We investigated the impact of P. gingivalis lipopolysaccharide (P. gingivalis-LPS) on gene expression in endothelial cells with comparison to Escherichia coli lipopolysaccharide (E. coli-LPS) and zymosan. Here, we showed that the expressions of interleukin-6 and tumor necrosis factor-α mRNA induced by P. gingivalis-LPS are much lower than those by E. coli-LPS, and that the expressions of interleukin-8 and hypoxia inducible factor-2α are also lower than those by zymosan. These effects of P. gingivalis-LPS-mediated alterations of gene expression were cancelled in the absence of fetal bovine serum in culture medium. Of note, P. gingivalis-LPS treatment reduced the gene expressions of tissue factor and plasminogen activating inhibitor-1 as opposed to either E. coli-LPS or zymosan treatment. Our finding suggests that alterations of gene expression pattern in endothelial cells mediated by P. gingivalis-LPS may contribute to the pathogenesis of vascular inflammatory diseases.
Subject
Porphyromonas gingivalis
lipopolysaccharide
inflammation
endothelial cells
blood coagulation
Journal Title
Shimane Journal of Medical Science
Volume
37
Issue
4
Start Page
123
End Page
132
ISSN
03865959
ISSN(Online)
24332410
Published Date
2020-12
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine