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language
eng
Author
Hisamatsu, Takashi
Miura, Katsuyuki
Arima, Hisatomi
Kadota, Aya
Kadowaki, Sayaka
Torii, Sayuki
Suzuki, Sentaro
Miyagawa, Naoko
Sato, Atsushi
Yamazoe, Masahiro
Fujiyoshi, Akira
Ohkubo, Takayoshi
Yamamoto, Takashi
Murata, Kiyoshi
Robert D. Abbott
Sekikawa, Akira
Horie, Minoru
Ueshima, Hirotsugu
the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research Group
Description
BACKGROUND: Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia.
METHODS AND RESULTS: In a population-based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross-sectional associations of smoking status, cumulative pack-years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima-media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle-brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16-2.79]; CIMT >1.0 mm, 1.88 [1.02-3.47]; AoAC >0, 4.29 [2.30-7.97]; and ankle-brachial index <1.1, 1.78 [1.16-2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13-3.34]; and AoAC >0, 2.55 [1.45-4.49]). Dose-response relationships of pack-years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle-brachial index, were observed among both current and former smokers, and even a small amount of pack-years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices.
CONCLUSIONS: Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation.
Subject
atherosclerosis
coronary artery calcification
cumulative pack‐years exposure
prevention
smoking
smoking cessation
Journal Title
Journal of the American Heart Association
Volume
5
Issue
9
Start Page
e003738
ISSN
20479980
Published Date
2016-08-29
DOI
PubMed ID
Publisher
American Heart Association ; American Stroke Association
NII Type
Journal Article
Format
PDF
Rights
© 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Text Version
出版社版
Gyoseki ID
e32262
OAI-PMH Set
Faculty of Medicine