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language
eng
Attribute
review
Author
Description
Both the disruption of endothelial homeostasis and tissue fibrosis are characteristics of diabetic complications. Accumulating evidence has revealed the significant role of vascular endothelial cells in tissue fibrogenesis via endothelial-mesenchymal transition (EndMT).
We have recently focused on the overexpression of endothelial dipeptidyl peptidase (DPP)-4, a critical pathological feature of the molecular mechanisms of EndMT, and suggest that DPP-4 inhibitors have great therapeutic potential via their antifibrotic effects. However, the diverse pleiotropic effects of DPP-4, both its enzyme-dependent and enzyme-independent effects, can be detrimental in some cases. This review provides an update on the biology of DPP-4, a profibrotic molecule, in addition to a discussion of cancer biology.
Subject
fibrosis
microRNA
integrin
extracellular matrix
cancer
Journal Title
Shimane Journal of Medical Science
Volume
36
Issue
2-3
Start Page
33
End Page
40
ISSN
03865959
ISSN(Online)
24332410
Published Date
2019-12
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine