File
language
eng
Author
Hashimoto, Michio
Haque, Abdul Md.
Sugioka, Kozo
Katakura, Masanori
Description
Twenty-two 5-week-old male Wistar rats fed an n-3 fatty acid-adequate diet were supplemented with docosahexaenoic acid (DHA) administered perorally for 14 weeks. Six weeks after the start of the administralion, the rats were for 5 weeks trained to acquire a reward at the end of each of 4 arms of an 8-arm radial maze. The retention test interposed with a delayed task (20-min interval after acquiring the first 2 rewards) was then given to each rat to determine spatial working memory retention DHA administration reduced the number of working memory errors after the 20-min interval in the retention test and tended to induce an increase in the DHA/arachidonic acid ratio in the hippocampus, indicating that chronic administration of DHA to rats fed an n-3 fatty acid-adequate diet is conducive to the improvement of working memory-related learning abiiity.
Journal Title
Shimane journal of medical science
Volume
22
Issue
2
Start Page
29
End Page
34
ISSN
03865959
ISSN(Online)
24332410
Published Date
2005-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html