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language
eng
Attribute
original article
Author
Bai Yunpeng
Nakatani Eiji
Iwahashi, Teruaki
Tabuchi, Yuki
Nariai, Yoshiki
Karino, Masaaki
Kanno, Takahiro
Huang Yongqing
Kagimura Tatsuo
Vieth Michael
Description
Development of a second primary tumor (SPT)contributes to a poor prognosis, even if the primary oral tumor (OT) was adequately managed. SPT develops as synchronous or metachronous esophageal cancers in 1-20% patients with oral squamous cell carcinoma (OSCC). This study aimed to evaluate the prevalence and associated factors for SPT of the upper digestive tract in 80 Japanese patients with OT (OSCC, oral intraepithelial neoplasia/carcinoma in situ : OIN/CIS, and verrucous carcinoma : VC). SPT were detected in 67 patients, 8 with esophageal carcinoma (EC), 2 with intraepithelial neoplasia (IN), 3 with gastric carcinoma (GC), 7 with epithelial dysplasia (ED), and 47 with other diseases. Malignant tumors (EC, IN, GC), were detected in 13/80 patients (16.3%). Univariate analysis showed that Brinkman index (BI) was a candidate associated factor. In the multivariate analysis, BI as a continuous variable was also a significant associated factor. We strongly suggest that endoscopic screening be performed to identify malignancies of the upper digestive tract in patients with OSCC, OIN/CIS and VC.
Subject
oral cancer
esophageal cancer
second primary cancer
associated factor
Journal Title
Shimane journal of medical science
Volume
32
Issue
2
Start Page
81
End Page
88
ISSN
03865959
ISSN(Online)
24332410
Published Date
2016
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e29189
OAI-PMH Set
Faculty of Medicine
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