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File
language
eng
Attribute
original article
Author
Tsunematsu, Koji
Nakatani Eiji
Iwahashi, Teruaki
Karino, Masaaki
Nariai, Yoshiki
Kanno, Takahiro
Kagimura Tatsuo
Description
This preliminary study evaluated the expression of human papilloma virus (HPV) 16, HPV18, and p16 as possible biomarkers to distinguish normal oral epithelium (NOE) from oral epithelial dysplasia (OED) and oral intraepithelial neoplasia (OIN). Subjects comprised 150 cases including 41 with OED, 30 with OIN, and 67 with oral squamous cell carcinoma (OSCC). NOE was also taken from 12 healthy participants. Staining indices of HPV16, HPV18, and p16 were immunohistochemically examined using paraffin-embedded specimens. A statistically significant difference was seen in the expression of HPV18 and p16 in OED/OIN compared with NOE and OSCC. Furthermore, regression tree analysis of independent variables, including p16 and HPV18 expression and the participants’ age, was performed to distinguish NOE from OED/OIN. In conclusion, this preliminary study demonstrated that p16 and HPV18 expression and participants’ age (60 years) can be used to distinguish NOE from OED/OIN.
Subject
HPV16 , HPV18 , p16
oral epithelial dysplasia
oral intraepithelial neoplasia
oral squamous cell carcinoma
Journal Title
Shimane journal of medical science
Volume
32
Issue
2
Start Page
69
End Page
79
ISSN
03865959
ISSN(Online)
24332410
Published Date
2016
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e28719
e29188
OAI-PMH Set
Faculty of Medicine
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