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language
eng
Author
SHIRAKAMI, Eri
Description
Once scar tissues mature, it is impossible for the surrounding tissue to regenerate normal dermal tissue. Therefore, it is essential to understand the fundamental mechanisms and establish effective strategies to inhibit aberrant scar formation. Hypertrophic scar formation is considered a result of the imbalance between extracellular matrix synthesis and degradation during wound healing. However, the underlying mechanisms of hypertrophic scar development are poorly understood. The purpose of this review was to outline the management in the early stage after wound healing to prevent hypertrophic scar formation, focusing on strategies excluding therapeutic agents of internal use. Treatment aimed at molecular targets, including cytokines, will be future options to prevent and treat hypertrophic scars. More basic studies and clinical trials, including combination therapy, are required to investigate the mechanisms and prevent hypertrophic scar formation.
Subject
Hypertrophic scar
Therapy
Intervention
Cytokines
Journal Title
Burns & Trauma
Volume
8
ISSN(Online)
2321-3876
Published Date
2020-01-27
DOI
Publisher
Oxford University Press
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e37106
OAI-PMH Set
Faculty of Medicine