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language
eng
Author
Tanaka, Osamu
Oki, Mitsuru
Gonda, Tatsuo
Domoto, Tokio
Description
In the nerve endings of the canine intestine, three types of the large granular vesicles found to coexist with small agranular vesicles were identified by conventional electron microscopy, on the basis of shape, size and electron density of their contents. They are characterized by the following profiles : (1) so-called large dense-cored vesicles (80-120 nm in diameter) whose contents were highly osmiophilic. Most of such vesicles had a clear-electron-transparent halo between the vesicle membrane and the granular core. These vesicles (LGV) usually coexist with a varying number of small agranular vesicles (50-70 nm in diameter) whose contents are assumed to be acetylcholine. (2) Large, electron-opaque vesicles (LOV) with a diameter of 140 to 200 nm. (3) electron-faint vesicles (LFV; 100-140nm in diameter) containing osmiophilic granular materials, with or without halos. Immunoelectron microscopy showed that vasoactive intestinal polypeptide (VIP)-like immunoprecipitates were localized to the large granular vesicles (Type 1 vesicles) which coexisted with small agranular vesicles (SAV), and VIP-immunoreactivity was not evident within the small granular vesicles (SGV).
Subject
VIP
axons
intestine
Journal Title
Shimane journal of medical science
Volume
5
Issue
2
Start Page
123
End Page
129
ISSN
03865959
ISSN(Online)
24332410
Published Date
1981-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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