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language
eng
Attribute
Review
Author
Yamamoto, Masahiro Internal Medicine 1, Shimane University Faculty of Medicine
Sugimoto, Toshitsugu Internal Medicine 1, Shimane University Faculty of Medicine
Description
Diabetic patients have a higher fracture risk than expected by their bone mineral density (BMD). Poor bone quality is the most suitable and explainable cause for the elevated fracture risk in this population. Advanced glycation end products (AGEs), which are diverse compounds generated via a non-enzymatic reaction between reducing sugars and amine residues, physically affect the properties of the bone material, one of a component of bone quality, through their accumulation in the bone collagen fibers. On the other hand, these compounds biologically act as agonists for these receptors for AGEs (RAGE) and suppress bone metabolism. The concentrations of AGEs and endogenous secretory RAGE, which acts as a “decoy receptor” that inhibits the AGEs-RAGE signaling axis, are associated with fracture risk in a BMD-independent manner. AGEs are closely associated with the pathogenesis of this unique clinical manifestation through physical and biological mechanisms in patients with diabetes mellitus.
Subject
Fracture
Bone quality
Material properties
Pentosidine
Crosslink
Receptor for advanced glycation end products (RAGE)
Journal Title
Current osteoporosis reports
Volume
14
Issue
6
Start Page
320
End Page
326
ISSN
15441873
Published Date
2016-12
DOI
PubMed ID
Publisher
Current Science
NII Type
Journal Article
Format
PDF
Rights
© The Author(s) 2016. This article is published with open access at Springerlink.com
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine