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language
eng
Author
Tanaka, Ken-ichiro Department of Internal Medicine 1, Shimane University Faculty of Medicine
Kanazawa, Ippei Department of Internal Medicine 1, Shimane University Faculty of Medicine
Sugimoto, Toshitsugu Department of Internal Medicine 1, Shimane University Faculty of Medicine
Description
BACKGROUND: Several studies showed that sarcopenia and visceral obesity are associated with arterial stiffness. Thus, their coexistence may be a crucial risk factor of arteriosclerosis. However, little is known about the cross relationships among muscle mass, visceral fat mass, and arterial stiffness in type 2 diabetes mellitus (T2DM).
METHODS: We recruited 97 postmenopausal women with T2DM and examine the association of muscle mass and visceral fat mass with brachial-ankle pulse wave velocity (baPWV). Relative skeletal muscle mass index (RSMI) and %trunk fat were evaluated by whole body dual-energy X-ray absorptiometry. Subcutaneous and visceral fat areas were measured by computed tomography.
RESULTS: Multiple regression analyses adjusted for age, duration of T2DM, systolic blood pressure, body mass index, HbA1c, serum creatinine, low-density lipoprotein-cholesterol, uric acid, and the usage of anti-hypertensive drug showed that RSMI was negatively associated with baPWV (β=-0.40, p=0.027), while %trunk fat and visceral fat area were positively associated with it (β=0.29, p=0.004 and β=0.51, p=0.001, respectively). Moreover, after additional adjustment for RSMI, %trunk fat and visceral fat area were positively associated with baPWV (β=0.26, p=0.010 and β=0.46, p=0.003, respectively) although the association between RSMI and baPWV became marginal after additional adjustment for %trunk fat or visceral fat area (β=-0.30, p=0.146 and β=-0.30, p=0.085, respectively).
CONCLUSIONS: Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM.
Subject
Muscle mass
Atherosclerosis
Diabetes mellitus
Sarcopenia
Obesity
Journal Title
Diabetes research and clinical practice
Volume
122
Start Page
141
End Page
147
ISSN
01688227
Published Date
2016-12
DOI
DOI Date
2017-07-18
PubMed ID
NCID
AA1044374X
Publisher
Elsevier
NII Type
Journal Article
Format
PDF
Rights
© 2016 Elsevier Ireland Ltd. All rights reserved.
Text Version
著者版
Gyoseki ID
e31957
OAI-PMH Set
Faculty of Medicine