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language
eng
Author
Ichinose, Mitsuyuki
Hirota, Akihiko
Description
To characterize the direct effects of wasp and bee venom peptides on mouse peritoneal macrophages, the effects of mastoparan and melittin on phagocytosis were examined. Mastoparan induced an enhancement of phagocytosis in a dose-dependnt manner up to 2x10^<-6>M. Melittin enhanced phagocytosis at lower concentrations, but the dose-response curve was bell-shaped. Even in Ca^<2+>-and Mg^<2+>-free solutions containing EGTA, which reduced extracellular Ca^<2+>, and BAPTA, which reduced intracellular free Ca^<2+>, phagocytosis was enhanced by mastoparan. The results of the present study suggest that the venom peptides, mastoparan and melittin, activate macrophage function.
Subject
macrophage
phagocytosis
mastoparan
melittin
Journal Title
Shimane journal of medical science
Volume
16
Issue
1
Start Page
15
End Page
18
ISSN
03865959
ISSN(Online)
24332410
Published Date
1998-06-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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