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language
eng
Author
Jidoi, Joji
Yamamoto, Shoso
Takagaki, Kenji
Yamasaki, Masahiro
Motizuki, Teruso
Description
A 10 mg dose of Cyclophosphamide was administered intraperitoneally to guinea pigs for 5 days at various stages of sensitization, and the effects of the drug for allergic contact dermatitis were studied by vascular permeability. This permeability was markedly increased in the group that was sensitized after administration of Cyclophosphamide, but the condition was inhibited in the group given the drug after sensitization but prior to provocation. Histopathological observations were made using indices of epidermic thickening (hypertrophy) and number of epidermic infiltrating cells. A more severe dermatitis was noted in the group given Cyclophosphamide prior to sensitization, as epidermic thickening in the animals in which the lesser concentration of DNCB had been applied, while there was an infiltration of cells in animals to which a higher concentration of DNCB had been given.
Subject
cyclophosphamide effects
allergic contact dermatitis
Journal Title
Shimane journal of medical science
Volume
4
Issue
2
Start Page
141
End Page
149
ISSN
03865959
ISSN(Online)
24332410
Published Date
1980-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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