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language
eng
Author
Miyake, Hitomi Department of Internal Medicine 1, Shimane University Faculty of Medicine
Kanazawa, Ippei Department of Internal Medicine 1, Shimane University Faculty of Medicine
Sugimoto, Toshitsugu Department of Internal Medicine 1, Shimane University Faculty of Medicine
Description
Mortality is increased in type 2 diabetes mellitus (T2DM). Although previous studies showed that decreased serum insulin-like growth factor-I (IGF-I) levels are associated with diabetic complications, little is known about the association between serum IGF-I level and the mortality in patients with T2DM. This is a historical cohort study with end-point of all-cause mortality in 234 men and 191 women with T2DM. Standard deviation of serum IGF-I [IGF-I (SD)] was calculated by adjusting for age and gender. Of 234 male and 191 female, 46 and 25 patients died, respectively, for the follow-up period of almost 7 years. Unadjusted survival analyses showed that lower IGF-I was associated with higher mortality in men and women (p<0.001 and p=0.004, respectively). In Cox regression analyses adjusted for age, duration of diabetes, body mass index, HbA1c, and serum creatinine, serum IGF-I was inversely associated with the mortality [men, hazard ratio (HR)=0.40, 95% confidence interval (CI)=0.25-0.64 per SD increase, p<0.001; women, HR=0.28, 95%CI 0.08-0.96, p=0.043]. When IGF-I was replaced to IGF-I (SD), the relationships are still significant. After additional adjustments for serum albumin, systolic blood pressure, ALT, LDL-cholesterol, smoking, and past history of cardiovascular disease, the association between serum IGF-I and the mortality in men remained significant (HR=0.31, 95%CI 0.15-0.65, p=0.002), but not in women. The present study showed that lower serum IGF-I levels were associated with the increased all-cause mortality in patients with T2DM, suggesting that serum IGF-I could be clinically useful for assessing the risk of mortality in the population.
Subject
Insulin-like growth factor-I
Type 2 diabetes mellitus
Mortality
HbA1c
Journal Title
Endocrine journal
Volume
63
Issue
9
Start Page
811
End Page
818
ISSN
09188959
Published Date
2016-09-30
DOI
PubMed ID
NCID
AA10901436
Publisher
Japan Endocrine Society
Publisher Aalternative
日本内分泌学会
NII Type
Journal Article
Rights
Copyright © The Japan Endocrine Society
Gyoseki ID
e31959
OAI-PMH Set
Faculty of Medicine