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eng
Author
Katagiri, Hiroshi 1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501
Sultana, Razia 1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501
Sanuki, Kaori 1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501
Nakayama, Satoru Departments of Obstetrics and Gynecology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka 4308558
Otsuki, Yoshiro Departments of Pathology, Seirei Hamamatsu General Hospital, Hamamatsu, Shizuoka 4308558
Ishikawa, Noriyuki Department of Organ Pathology, Shimane University School of Medicine, Izumo, Shimane 6938501
Description
The clinicopathological significance and prognostic value of the expression of proteins associated with autophagy, beclin 1 (BECN1), 1A/1B‑light chain 3 (LC3) and high mobility group box‑1 protein (HMGB‑1), were investigated in patients with ovarian carcinoma, receiving combination chemotherapy with a platinum agent and a taxane. Immunohistochemical staining was performed for autophagy‑associated proteins in tumor tissues from 141 patients with ovarian carcinoma. Clinical data were collected retrospectively by reviewing medical charts, and the association between protein expression, clinicopathological features and survival was investigated. Amongst 141 ovarian carcinoma samples, the loss of BECN1, LC3, and HMGB‑1 expression was identified in 59 (41.8%), 35 (24.8%), and 66 (46.8%) samples, respectively. Clinicopathological factors were not significantly associated with the loss of BECN1 expression. However, significant associations were demonstrated between the expression of BECN1, LC3, and HMGB‑1. In addition, loss of BECN1 expression demonstrated a significant association with poor progression‑free and poor overall survival. Multivariate analysis demonstrated that loss of BECN1 expression and postoperative residual tumor were significant independent predictors of poor progression‑free survival and poor overall survival. These results indicated that loss of BECN1 expression in ovarian carcinoma is a negative prognosticator in patients receiving platinum‑based chemotherapy. Assessment of BECN1 expression may be useful for predicting an unfavorable response to platinum‑based chemotherapy in ovarian carcinoma.
Subject
ovarian carcinoma
beclin 1
survival
platinum
taxane
Journal Title
Oncology Letters
Volume
15
Issue
1
Start Page
1170
End Page
1176
ISSN
1792-1074
ISSN(Online)
1792-1082
Published Date
2017-11-9
DOI
Publisher
Spandidos Publications
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e36787
OAI-PMH Set
Faculty of Medicine