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language
eng
Author
Hashimoto, Michio
Kato, Setsushi Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane 696-0001, Japan.
Shahdat Hossain
Ohno, Miho Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane 696-0001, Japan.
Description
Perilla oil (PO), rich in α-linolenic acid (LNA, C18:3, ω-3), is increasingly alleged to have numerous health benefits in humans. However, the current reports detailing the effects of PO on human mental health are not adequate. Therefore, in the current investigation we compared the effects of PO or placebo treatment on the mental condition of healthy adult Japanese volunteers. At baseline and after 12 months of treatment, mental health condition was assessed using the Zung Self-Rating Depression Scale (SDS) and Apathy Scale, and serum biochemical parameters were determined. From baseline to 12 months of intervention, both SDS depression and apathy scores improved significantly in the PO-administered group. Compared to those of control group, serum norepinephrine and serotonin levels after 12 months decreased in the PO-administered group. The enhanced mental state observed in PO-subjects was accompanied by LNA level increases in erythrocyte plasma membranes. Our data demonstrate that PO intake enhances blood LNA levels and may maintain healthy mental conditions in adult subjects.
Subject
apathy
depression
mental health
perilla oil
α-linolenic acid
ω-polyunsaturated fatty acid
Journal Title
Foods
Volume
9
Issue
4
ISSN
2304-8158
DOI
PubMed ID
Publisher
MDPI AG
NII Type
Journal Article
Format
PDF
Relation
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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