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Original article
Author
Ishihara, Tomoe Department of Ophthalmology
Kaidzu, Sachiko Department of Ophthalmology
KIMURA, Hideto Kotobuki Seika Co., Ltd.
KOYAMA, Yasuro Kotobuki Seika Co., Ltd.
MATSUOKA, Yotaro Department of Ophthalmology
Ohira, Akihiro Department of Ophthalmology
Description
Retinal light-induced damage model rats used
in age-related macular degeneration (AMD) studies
clarified that antioxidants decrease the damage.
The seed shells of Japanese horse chestnuts have
antioxidant activity with polyphenols. We studied
that protective effect of the polyphenols from lightinduced
damage. Polyphenols fraction (PF) was extracted
and separated from the seed shells. Antioxidant
activities of PF were measured. Intraperitoneal
administration (IP) and oral administration (PO) of
PF was evaluated protective effects by flash electroretinograms
(ERGs) and outer nuclear layer (ONL)
thickness measurement. IP of PF (100 mg/kg body
weight [BW] and phenyl N-tert-butyl nitrone (PBN)
(50 mg/kg BW) suppressed decrease of ERG amplitude
significantly. And then, decrease of ONL
thickness was suppressed by PF (25, 50 and 100
mg/kg BW) and PBN (50 mg/kg BW). PO of PF
(100 mg/kg BW) protects retinas from light-induced
damage, as well as PBN (10 and 50 mg/kg BW).
Our results indicate that PF alleviates light-induced
retinal damage and potentially useful for the prevention
of AMD.
Subject
retina protection
Japanese horse chestnuts
Aesculus turbinata BLUME
polyphenol
antioxidant
Journal Title
Shimane Journal of Medical Science
Volume
34
Issue
3
Start Page
99
End Page
107
ISSN
03865959
ISSN(Online)
24332410
Published Date
2018-03-31
NCID
AA00841586
Publisher
Faculty of Medicine, Shimane University
Publisher Aalternative
島根大学医学部
NII Type
Departmental Bulletin Paper
Format
PDF
Rights
Faculty of Medicine, Shimane University
Text Version
出版社版
Gyoseki ID
e34664
OAI-PMH Set
Faculty of Medicine
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