Multicomponent Synthesis of Imidazo[1,2-a]pyridines: Aerobic Oxidative Formation of C–N and C–S Bonds by Flavin–Iodine-Coupled Organocatalysis

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ID	53851
File	Multicomponent Synthesis of Imidazo[1,2-a]pyridines: Aerobic Oxidative Formation of C–N and C–S Bonds by Flavin–Iodine-Coupled Organocatalysis 940 KB
language	eng
Author	Okai, Hayaki Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan Tanimoto, Kazumasa Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan Ohkado, Ryoma Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan Iida, Hiroki
Description	Herein, we report an aerobic oxidative C–N bond-forming process that enables the facile synthesis of imidazo[1,2-a]pyridines and takes advantage of a coupled organocatalytic system that uses flavin and iodine. Furthermore, the dual catalytic system can be applied to the one-pot, three-step synthesis of 3-thioimidazo[1,2-a]pyridines from aminopyridines, ketones, and thiols.
Subject	Flavins Chemical synthesis Catalysts Oxygen Catalytic reactions
Journal Title	Organic Letters
Volume	22
Issue	20
Start Page	8002
End Page	8006
ISSN	1523-7060
Published Date	2020-10-16
DOI	10.1021/acs.orglett.0c02929
Publisher	American Chemical Society
NII Type	Journal Article
Format	PDF
Text Version	著者版
Gyoseki ID	38960
OAI-PMH Set	Faculty of Science and Engineering