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ID 4449
Title Transcription
ヒト センショクタイ オ ホユウスル キメラマウス タイシ ニ オケル ハッセイ イジョウ
Title Alternative (English)
Developmental anomalies in the foetuses of a chimeric mouse containing a human chromosome
File
language
jpn
Author
Funaki, Kenji
Description
Chimeric mice containing a human chromosome were produced by introducing a human chromosome into mouse embryonic stem cells via microcell-mediated chromosome transfer.
In present study, the dead foetuses of the chimeric mice containing a human chromosome 2-derived fragment (hChr.2f) or a human chromosome 21 (hChr.21) were studied anatomically in order to examine the effects of introduction of a human chromosome to mouse. Polydactyly were obsered in almost of the chimeric foetuses containing hChr.2f, but were not detected in the chimeric foetuses containing hChr.21. Aplasia of the sternum and delayed ossification or deletion of the cervical vertebrae centrum were universally observed in both the chimericfoetuses. Histological abnormalities in heart and liver were frequently detected in both the chimeric foetuses. Interestingly, the number of germ cells decreased remarkably in all of the chimeric foetuses containing hChr.21.
Journal Title
Memoirs of the Faculty of Education, Shimane University. Natural science
Volume
35
Start Page
1
End Page
8
ISSN
05869943
Published Date
2001-12-01
NCID
AN00107941
Publisher
島根大学教育学部
Publisher Aalternative
The Faculty of Education Shimane University
NII Type
Departmental Bulletin Paper
OAI-PMH Set
Faculty of Education
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