ダウンロード数 : ?
ファイル
言語
英語
著者
田中 賢一郎 島根大学医学部内科学第一
金沢 一平 島根大学医学部内科学第一
杉本 利嗣 島根大学医学部内科学第一
内容記述(抄録等)
BACKGROUND: Several studies showed that sarcopenia and visceral obesity are associated with arterial stiffness. Thus, their coexistence may be a crucial risk factor of arteriosclerosis. However, little is known about the cross relationships among muscle mass, visceral fat mass, and arterial stiffness in type 2 diabetes mellitus (T2DM).
METHODS: We recruited 97 postmenopausal women with T2DM and examine the association of muscle mass and visceral fat mass with brachial-ankle pulse wave velocity (baPWV). Relative skeletal muscle mass index (RSMI) and %trunk fat were evaluated by whole body dual-energy X-ray absorptiometry. Subcutaneous and visceral fat areas were measured by computed tomography.
RESULTS: Multiple regression analyses adjusted for age, duration of T2DM, systolic blood pressure, body mass index, HbA1c, serum creatinine, low-density lipoprotein-cholesterol, uric acid, and the usage of anti-hypertensive drug showed that RSMI was negatively associated with baPWV (β=-0.40, p=0.027), while %trunk fat and visceral fat area were positively associated with it (β=0.29, p=0.004 and β=0.51, p=0.001, respectively). Moreover, after additional adjustment for RSMI, %trunk fat and visceral fat area were positively associated with baPWV (β=0.26, p=0.010 and β=0.46, p=0.003, respectively) although the association between RSMI and baPWV became marginal after additional adjustment for %trunk fat or visceral fat area (β=-0.30, p=0.146 and β=-0.30, p=0.085, respectively).
CONCLUSIONS: Reduced muscle mass and increased visceral fat are independently associated with increased arterial stiffness in postmenopausal women with T2DM.
主題
Muscle mass
Atherosclerosis
Diabetes mellitus
Sarcopenia
Obesity
掲載誌名
Diabetes research and clinical practice
122
開始ページ
141
終了ページ
147
ISSN
01688227
発行日
2016-12
DOI
DOI公開日
2017-07-18
PubMed ID
NCID
AA1044374X
出版者
Elsevier
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© 2016 Elsevier Ireland Ltd. All rights reserved.
著者版/出版社版
著者版
業績ID
e31957
部局
医学部