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ファイル
言語
英語
著者
田中 賢一郎
内容記述(抄録等)
Advanced glycation end-products (AGEs) play important roles in the progression of diabetic complications. Although sarcopenia is recently recognized as another complication associated with diabetes mellitus, its mechanism still remains unclear. In this study, we investigated the relationship between serum levels of pentosidine, which is one of AGEs, and insulin-like growth factor-I (IGF-I) vs. skeletal muscle mass by whole body dual-energy x-ray absorptiometry in 133 postmenopausal women with type 2 diabetes. Relative skeletal muscle mass index (RSMI) was calculated by following formula; appendicular skeletal muscle mass divided by height in meters squared. Simple correlation analyses showed that serum pentosidine levels were significantly and negatively correlated with muscle mass of legs (r=-0.21, p=0.017) and RSMI (r=-0.18, p=0.022), and that IGF-I was significantly and positively correlated with muscle mass of arms and legs (r=0.23, p=0.008 and r=0.30, p=0.001, respectively) as well as RSMI (r=0.20, p=0.022). Moreover, after adjusting for age, duration of diabetes, serum creatinine, HbA1c, and IGF-I, pentosidine was significantly and negatively associated with RSMI (β=-0.27, p=0.018) and marginally with muscle mass of legs (β=-0.18, p=0.071). The associations between IGF-I and indices of muscle mass such as arms, legs and RSMI were still significant after additional adjustment for pentosidine (p=0.016, 0.019 and 0.021, respectively). These findings indicate that increased serum pentosidine and decreased IGF-I are independent risk factors for loss of muscle mass in postmenopausal women with type 2 diabetes.
主題
pentosidine
skeletal muscle mass
sarcopenia
diabetes mellitus
IGF-I
掲載誌名
Experimental and clinical endocrinology & diabetes
124
3
開始ページ
163
終了ページ
166
ISSN
09477349
発行日
2016-03
DOI
DOI公開日
2017-04-17
PubMed ID
出版者
Thieme
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
© Georg Thieme Verlag KG Stuttgart・New York
著者版/出版社版
著者版
業績ID
e28667
e28666
部局
医学部