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ファイル
言語
英語
属性
原著論文
著者
顔 青 発生生物学講座
小川 典子 発生生物学講座
松本 暁洋 発生生物学講座
毓起 党 銀川中国医学病院
大谷 浩 発生生物学講座
内容記述(抄録等)
Effects of Kampo formulas which have been long
used clinically for obese patients remain unclear at
the cellular level. The objective of this study is to
investigate the effects of 8 commonly-used Kampos
on the differentiation and proinflammatory cytokines
expression of 3T3-L1 cells. 3T3-L1 preadipocytes
were induced differentiation being treated with test
8 Kampos through the induction period. Oil red O
staining and mRNAs expressions of peroxisome proliferator-
active receptor-γ (PPARγ) and adiponectin
were examined to evaluate effects of the Kampos
on the differentiation. Tumor necrosis factor-alpha
(TNF-α), interleukin-6, and monocyte chemoattractant
protein-1 (MCP-1) mRNAs were examined to
investigate the anti-inflammatory effects of the Kampos.
PPARγ and/or adiponectin, as well as MCP-1
and/or TNF-α mRNAs were significantly decreased
by Boiogito and a few other Kampos when compared
with the control. These results at the cellular
level are compatible with the clinical beneficial effects
of these Kampos.
主題
3T3-L1
differentiation
inflammation
PPARγ
MCP-1
掲載誌名
Shimane Journal of Medical Science
34
3
開始ページ
109
終了ページ
118
ISSN
03865959
ISSN(Online)
24332410
発行日
2018-03-31
NCID
AA00841586
出版者
Faculty of Medicine, Shimane University
出版者別表記
島根大学医学部
資料タイプ
紀要論文
ファイル形式
PDF
権利関係
Faculty of Medicine, Shimane University
著者版/出版社版
出版社版
業績ID
e36081
e33157
部局
医学部
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