ダウンロード数 : ?
ID 48960
ファイル
言語
英語
属性
Research Article
著者
Hie LimKim Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Takeshi Igawa Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, Higashihiroshima, Hiroshima 739-8526, Japan
Tasuku Nishioka Center for the Promotion of Integrated Sciences, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Satoko Kaneko Laboratory of Plant Genetics, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
Yukako Katsura Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Naoyuki Takahata The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
Yoko Satta Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies (SOKENDAI), Hayama, Kanagawa 240-0193, Japan
内容記述(抄録等)
We report the results of an extensive investigation of genomic structures in the human genome, with a particular focus on relatively large repeats (>50 kb) in adjacent chromosomal regions. We named such structures “Flowers” because the pattern observed on dot plots resembles a flower. We detected a total of 291 Flowers in the human genome. They were predominantly located in euchromatic regions. Flowers are gene-rich compared to the average gene density of the genome. Genes involved in systems receiving environmental information, such as immunity and detoxification, were overrepresented in Flowers. Within a Flower, the mean number of duplication units was approximately four. The maximum and minimum identities between homologs in a Flower showed different distributions; the maximum identity was often concentrated to 100% identity, while the minimum identity was evenly distributed in the range of 78% to 100%. Using a gene conversion detection test, we found frequent and/or recent gene conversion events within the tested Flowers. Interestingly, many of those converted regions contained protein-coding genes. Computer simulation studies suggest that one role of such frequent gene conversions is the elongation of the life span of gene families in a Flower by the resurrection of pseudogenes.
掲載誌名
International Journal of Evolutionary Biology
2012
開始ページ
1
終了ページ
11
ISSN
2356-6140
ISSN(Online)
1537-744X
発行日
2012-01-19
DOI
出版者
Hindawi Publishing Corporation
資料タイプ
学術雑誌論文
ファイル形式
PDF
権利関係
Copyright © 2012 Hie Lim Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
著者版/出版社版
出版社版
業績ID
e29713
部局
他機関
備考
Article ID 917678