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ファイル
言語
日本語
属性
原著論文
著者
LiJun CHEN
Taooka Yasuyuki
Ohe Miki
高橋 仁
須谷 顕尚
久良木 隆繁
Wang XU
XiaoBo HUANG
内容記述(抄録等)
Chronic obstructive pulmonary disease(COPD)is characterized by chronic inflammation. Cyclooxygenase-2(COX-2) plays a very important role in the progress of inflammation. Several potentially functional polymorphisms of the COX-2 gene were identified and proposed to be associated with COPD susceptibility. In this study, we aimed to investigate a possible association between COX-2(-765G>C;-1195G>A) polymorphisms and the risk of COPD in the Japanese population. COX-2 gene polymorphisms were identified by polymerase chain reaction-restriction fragment-length polymorphism(PCRRFLP)
in 103 Japanese patients with COPD and 129 healthy controls. The distributions of genotypes and alleles were compared by using the χ2 test. The odds ratios(OR) and 95% confidence intervals (95%CI) were calculated by a logistic regression analysis. The frequencies of the GG, GC, CC genotypes of COX-2-765G>C and GG, GA, AA genotypes
of COX-2-1195G>A in the COPD group were 94.2%, 5.8%, 0.0% and 14.6%, 40.8%, 44.6%, respectively. These frequencies in control group were 89.1%, 10.9%, 0.0% and 23.3%, 44.9%, 31.8%, respectively. The COX-2-1195AA was more prevalent in the COPD group(44.6%) than the control group (31.8%). The distribution of the -765C was higher
in the control group(5.5%) in comparison to the COPD group(2.9%). In conclusion, the COX-2-1195AA genotype was associated with an increased risk for COPD in the Japanese population.
掲載誌名
Shimane journal of medical science
28
2
開始ページ
69
終了ページ
74
ISSN
03865959
ISSN(Online)
24332410
発行日
2012-02-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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