ダウンロード数 : ?
ファイル
言語
英語
属性
原著論文
著者
仁尾 義則
井口 千景
壷井 和彦
西 健
橋本 幸直
Takamura, Michio
Takeda, Hiroshi
Omori, Hiroshi
小池 誠
Sato, Yoshitoshi
遠藤 真一郎
Ogo, Kazumasa
Yamaguchi, Kazushige
Tsuji, Munechika
Toga, Tomoko
内容記述(抄録等)
Prolactin (PRL) is associated with lactation, and also plays an important role in the development and progression of breast cancer (BC). PRL exerts its effects via its receptor, the PRL-receptor (PRLR), so it is beneficial to study the distribution and alteration in expression of PRLR in order to elucidate the biologic effects of PRL on BC. In 84 BCs, PRLR expression was examined by an immunohistochemical technique. PRLR immunoreactivity was detected mainly in the cytoplasm. And the overall positive rate (cut-off > 10%) was 71% (60/84), while invasive BC showed a significantly higher positive rate (75%, 57/76) than non-invasive BC (38%, 3/8) (p=0.0264). The PRLR expression showed no correlation with age, primary tumor, nodal involvement, distant metastasis, or clinical stage; however, it was significantly correlated with estrogen receptor (ER) expression (p=0.0361), especially in invasive BC (p=0.0098), but not with the progesterone receptor (PgR) expression or HER-2 expression. PRLR was highly expressed in IDC ( invasive ductal carcinoma) and correlated with ER expression, suggesting that PRL and PRLR may play important roles in the development and progression of ER (+) BC.
掲載誌名
Shimane journal of medical science
28
1
開始ページ
1
終了ページ
6
ISSN
03865959
ISSN(Online)
24332410
発行日
2011-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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