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ファイル
言語
英語
属性
原著論文
著者
高塚 尚和
Fujii, Yoshimi
Hsiao-Chi, Chung
Muro, Tomonori
Kataoka, Kaori
内容記述(抄録等)
Deoxyribonuclease I (DNase I) polymorphism n exon 8 (A2317G) designated as DNASEI is considered to be one of the susceptibility genes for gastric and colorectal carcinoma, and myocardial infarction. Moreover, the presence of a variable number of tandem repeat (VNTR) polymorphism, designated as HumDN1, in intron 4. was found. In this study, the simultaneous genotyping of DNASEI and HumDN1 polymorphisms within the DNase I gene was performed in Ovambo, Turk, Mongolian, Korean and Japanese populations. Genotype distributions of DNASEI and HumDNI Ioci differed among these populations. While there was a general uniformity for the two polymorphisms in the three Asian populatlons, a significant difference in genotype distribution were found between the Ovambo and Turk populations. The DNASE1*1 and HumDN1*3 alleles were found to be the most predominant in the Ovambos, with the Turks showing the highest allele frequency for DNASE1*2, HumDN1*4 and HumDN1*5. From this study, there was the existence of a certain genetic heterogeneity in the distribution of these two DNase l polymorphisms. Furthermore, linkage disequilibrium between these two polymorphisms was revealed in all of the populations except the Ovambos. The combination of the two polymorphisms within a DNase I gene may be potentially useful for clinical purposes and in population genetic studies.
掲載誌名
Shimane journal of medical science
24
開始ページ
15
終了ページ
20
ISSN
03865959
ISSN(Online)
24332410
発行日
2007-12-01
NCID
AA00841586
出版者別表記
Shimane University Faculty of Medicine
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
備考
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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