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ファイル
言語
英語
著者
正木 洋治
谷川 敬一郎
大国 智司
土山 真一
野手 信哉
内容記述(抄録等)
The effects of hypoglycemic sulfonylurea gliclazide on insulin release and its interaction with tumor-promoting phorbol ester in rat pancreatic islets were examined. Lower concentrations of gliclazide stimulated insulin release in the presence of 5.6mM glucose, but the addition of high concentrations of gliclazide resulted in a tendency to reduce insulin release. The stimulatory action of gliclazide on insulin release was abolished in the absence of Ca^<2+>. Gliclazide also failed to stimulate insulin release in the presence of 16.7mM glucose, and 50μM gliclazide inhibited insulin release significantly. A synergistic effect of gliclazide on insulin release was observed in the presence of phorbol ester 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Such a combined effect of gliclazide with TPA was inhibited when extracellular Ca^<2+> was not present. These results indicate that gliclazide stimulates insulin release to affect Ca^<2+> handling in the pancreatic B cell.
主題
Sulfonylurea
insulin release
phorbol ester
掲載誌名
Shimane journal of medical science
10
1
開始ページ
1
終了ページ
8
ISSN
03865959
ISSN(Online)
24332410
発行日
1986-09-01
NCID
AA00841586
出版者別表記
Shimane Medical University
資料タイプ
紀要論文
ファイル形式
PDF
著者版/出版社版
出版社版
部局
医学部
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