File
language
eng
Author
ADACHI, Koji
Kawakami, Koshi
Description
All-trans retinoic acid (ATRA) is valuable in differentiation therapy for acute promyelocytic leukemia (APL). However, ATRA has had limited success as a single agent, due to the development of resistance. We found that tamoxifen effectively enhanced the differentiation-inducing effect of ATRA. Tamoxifen alone inhibited the proliferation of myeloid leukemia cell lines while only slightly increasing morphologic differentiation. Tamoxifen effectively enhanced the growthinhibiting actions of various differentiation-inducing agents. ATRA in the presence of tamoxifen increased NBT reduction and the expression of CD11b in HL-60 cells more effectively than ATRA alone. Tamoxifen also enhanced the differentiation induced by the other inducers tested. ATRA induced the differentiation of APL cell lines NB4 and HT93 and APL cells in primary culture, and this differentiation was also enhanced by tamoxifen. Tamoxifen is one of the most widely used drugs for the treatment of cancer and has few side effects. The combination of ATRA and tamoxifen might be considered for the treatment of APL patients in whom it can be difficult to apply arsenic trioxide or anthracyclines.
Subject
acute promyelocytic leukemia cells
differentiation
growth inhibition
tamoxifen
all-trans retinoic acid
Journal Title
INTERNATIONAL JOURNAL OF ONCOLOGY
Volume
48
Start Page
1095
End Page
1102
ISSN
1019-6439
Published Date
2016
DOI
Publisher
Spandidos Publications
NII Type
Journal Article
Format
PDF
Text Version
出版社版
OAI-PMH Set
School of Medicine, Faculty of Medicine