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Title Transcription
コウソテキ エンキ コウカン ハンノウ オ リヨウシタ チアミン アナログ ノ チョウセイ
Title Alternative (English)
Enzymic Preparation of Thiamine Analogues by the Utilization of a Base-Exchange Reaction
File
language
jpn
Author
Mochida, Kazuo
Nakamura, Toshiie
Fujita, Keiji
Description
The enzymic preparation of thiamine analogues was examined. Thiaminase I catalyzes an exchange reaction of the thiazole moiety of thiamine with aniline, pyridine, cysteine etc., liberating 2-hydroxyalkyl-4-methyl-5-β-hydroxyethylthiazole. Ten kinds of(2-methyl -4-amino-5-pynmidinyl)methyl derivatives(Pm derivatives) were preparated by the uti lization of the base-exchange reaction of free or Sepharose 4B-immobilized thiaminase I. Pm derivatives isolated were Pm-thiophenol, Pm-o-aminothiophenol, Pm-benzoic acid, Pmaniline, Pm-pyridine, Pm-α-pycoline, Pm-nicotinamide, Pm-quinoline, Pm-pyperidine, and Pm-cysteine. The physicochemical parameters of these compounds were determined.
Journal Title
Bulletin of the Faculty of Agriculture, Shimane University
Volume
18
Start Page
188
End Page
192
ISSN
0370940X
Published Date
1984-12-20
NCID
AN00108015
Publisher
島根大学農学部
Publisher Aalternative
Shimane University, Faculty of Agriculture
NII Type
Departmental Bulletin Paper
OAI-PMH Set
Faculty of Life and Environmental Science
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