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File
language
eng
Attribute
original article
Author
Miyazaki, Kohji
Description
Buserelin acetate, a synthetic analog of gonadotropin-releasing hormone(GnRH), is widely used in the treatment of endometriosis and uterine leiomyoma. This study sought to identify predictors of side effects of buserelin treatment. The medical records of 52 patients who received buserelin treatment were reviewed. The patients were divided into two groups based on the presence or absence of the common side effects of abnormal vaginal bleeding and climacteric symptoms, and compared in terms of age, height, weight, BMI, and basal gonadotropin level. Abnormal vaginal bleeding and climacteric symptoms were reported in 69.2% and 61.5% of the patients, respectively. Among patients who did not report these side effects, mean weight and mean BMI were significantly higher than those of patients who reported the side effects. Mean basal level of serum gonadotropins, the LH:FSH ratio, and patient menstrual history were not related to the incidence of these side effects. Those with higher weight and BMI are less likely to have buserelin effects, and those with lower weight and BMI are more likely to have these side effects. So, lower weight and BMI might be a predictors for two common side effects of monthly buserelin treatment.
Journal Title
Shimane journal of medical science
Volume
28
Issue
1
Start Page
21
End Page
26
ISSN
03865959
ISSN(Online)
24332410
Published Date
2011-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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