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language
eng
Author
Nakazawa, Yoshio
Nihei, Toyo
Morioka, Shigefumi
Moriyama, Katsutoshi
Yamori, Yukio
Description
After the ligation of coronary artery for 1 hour (1-hr group), 2 hours (2-hr group) and 4 hours (4-hr group), we investigated myocardial viability through the alterations in sarcolemmal function with measurements of regional myocardial blood flow (RMBF) and sarcolemmal Na^+, K^+-ATPase (ATPase) activity, comparing these groups with a permanently occluded group (permanent group). RMBF was measured in the ischemic region using hydrogen gas generated by electrolysis. Sarcolemmal membrane debris was prepared from ischemic, marginal and non-ischemic regions of the myocardium 7 days after reperfusion. Seven days after reperfusion, RMBF in 1-hr group recovered to control value. Reduction of RMBF in 2-hr group was significantly less than that of RMBF in parmanent group. There was no significant difference in RMBF between 4-hr group and permanent group. In the ischemic region, reduction of ATPase activity in 1-hr 2-hr group was significantly less than that of enzyme activity in permanent group. There was no difference in enzyme activity between 4-hr agoup and permanent group. In the marginal region, there was no difference in ATPase activity between the reperfusion group and the permanent group. These results show that in 4 hours or more after coronary artery occlusion, little salvage of the myocardium can be induced by acute reperfusion.
Subject
Na^+, K^+-ATPase
regional myocardial blood flow
reperfusion
Journal Title
Shimane journal of medical science
Volume
10
Issue
2
Start Page
58
End Page
71
ISSN
03865959
ISSN(Online)
24332410
Published Date
1986-12-01
NCID
AA00841586
Publisher Aalternative
Shimane Medical University
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
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