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language
eng
Attribute
original article
Author
Tongu, Miki
Hashimoto, Hideki
Yamada, Takaya
Yasuda Toshihiro
Description
In the present study, acute toxicity of ZnO NPs and silica-coated ZnO NPs following intravenous injection using mice were evaluated. ZnO dispersion (average size: 148 nm) at a dose of 10 mg/kg and 30 mg/kg, and a Silica-coated ZnO (ZnOSiO2)at a dose of 10 mg/kg, 30 mg/kg and 130 mg/kg were injected intravenously via tail vein of mouse. All mice (n = 6) died within 5 min following intravenous ZnO dose of 10 mg/kg and 30 mg/kg. Impaired motility and convulsion were observed before the death. On the other hand, silica-coating can reduce the toxicity. All mice survived and impaired motility was not observed following intravenous ZnO-SiO2 (average size: 81 nm) treatment at the same dose of ZnO NPs. At a dose of 130 mg/kg, impaired motility and convulsion was observedin all mice, one mouse out of 5 mice died after 5 min. Blood coagulation was observed in all died mice,which may be related to the toxicity of ZnO NPs.
Subject
Acute toxicity
Bio-imaging
Nanoparticles
Intravenous injection
ZnO
Silica-coated ZnO
Journal Title
Shimane journal of medical science
Volume
31
Issue
1
Start Page
7
End Page
11
ISSN
03865959
ISSN(Online)
24332410
Published Date
2014-12-01
NCID
AA00841586
Publisher
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
Gyoseki ID
e26358
e26358
e25134
e25143
OAI-PMH Set
Faculty of Medicine
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