ダウンロード数 : ?
File
language
eng
Attribute_del
Review
Author
Description
The number of patients with osteoporosis and diabetes is rapidly increasing all over the world. Bone is recently recognized as an endocrine organ. Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and secreted into the circulation, regulates glucose homeostasis by stimulating insulin expression in pancreas and adiponectin expression in adipocytes, resulting in improving glucose intolerance. On the other hand, insulin and adiponectin stimulate osteocalcin expression in osteoblasts, suggesting that positive feedforward loops exist among bone, pancreas, and adipose tissue. In addition, recent studies have shown that osteocalcin enhances insulin sensitivity and the differentiation in muscle, while secreted factors from muscle, myokines, regulate bone metabolism. These findings suggest that bone metabolism and glucose metabolism are associated with each other through the action of osteocalcin. In this review, I describe the role of osteocalcin in the interaction among bone, pancreas, brain, adipose tissue, and muscle.
Subject
Osteocalcin
Undercarboxylated osteocalcin
Glucose
Insulin
Adiponectin
Glucagon-like peptide-1
Diabetes mellitus
Journal Title
World journal of diabetes
Volume
6
Issue
18
Start Page
1345
End Page
1354
ISSN
19489358
Published Date
2015-12
DOI
PubMed ID
Publisher
Baishideng Publishing Group
NII Type
Journal Article
Format
PDF
Rights
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Text Version
出版社版
Gyoseki ID
e28550
OAI-PMH Set
University Hospital, Faculty of Medicine
このエントリーをはてなブックマークに追加