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File
language
eng
Attribute
original article
Author
Nio, Yoshinori
Iguchi, Chikage
Tsuboi, Kazuhiko
Nishi, Takeshi
Hashimoto, Koji
Takamura, Michio
Takeda, Hiroshi
Omori, Hiroshi
Koike, Makoto
Sato, Yoshitoshi
Endo, Shinichiro
Ogo, Kazumasa
Yamaguchi, Kazushige
Tsuji, Munechika
Toga, Tomoko
Description
Prolactin (PRL) is associated with lactation, and also plays an important role in the development and progression of breast cancer (BC). PRL exerts its effects via its receptor, the PRL-receptor (PRLR), so it is beneficial to study the distribution and alteration in expression of PRLR in order to elucidate the biologic effects of PRL on BC. In 84 BCs, PRLR expression was examined by an immunohistochemical technique. PRLR immunoreactivity was detected mainly in the cytoplasm. And the overall positive rate (cut-off > 10%) was 71% (60/84), while invasive BC showed a significantly higher positive rate (75%, 57/76) than non-invasive BC (38%, 3/8) (p=0.0264). The PRLR expression showed no correlation with age, primary tumor, nodal involvement, distant metastasis, or clinical stage; however, it was significantly correlated with estrogen receptor (ER) expression (p=0.0361), especially in invasive BC (p=0.0098), but not with the progesterone receptor (PgR) expression or HER-2 expression. PRLR was highly expressed in IDC ( invasive ductal carcinoma) and correlated with ER expression, suggesting that PRL and PRLR may play important roles in the development and progression of ER (+) BC.
Journal Title
Shimane journal of medical science
Volume
28
Issue
1
Start Page
1
End Page
6
ISSN
03865959
ISSN(Online)
24332410
Published Date
2011-12-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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