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File
language
eng
Attribute
original article
Author
Nagami, Haruhiko
Matsui, Yuzuru
Description
The efficacy and safety of the association of nonsteroidal anti-inflammatory drugs(NSAIDs)and pregabalin(commonly used to control neuropathic pain), compared with the monotherapy of each, were evaluated for the treatment of chronic low back pain(CLBP), a condition known to be due to neuropathic as well as nociceptive pain mechanisms. In the present prospective study, 71 patients received three consecutive 16-week treatment regimes, randomly assigned: NSAIDs only, pregabalin only, and NSAIDs plus pregabalin. All patients were assessed by using a visual analogue scale(VAS, 0-100 mm). The present study demonstrated that, in the patients with CLBP treated by combination therapy of pregabalin in addition to NSAIDs, the mean VAS reduction ratio was dramatically decreased compared with each monotherapy at 8, 12, and 16 weeks. That combination therapy was effective in reducing CLBP. As regards the adverse effects of each therapy, the frequency of dizziness was higher in the  patients treated with pregabalin only and with the combination treatment with NSAIDs plus pregabalin. Gastrointestinal adverse effects were recognized in the NSAID treatment group, although there was not a significant difference and such adverse effects were not recognized in Group B and Group C. In conclusion, it was emonstrated that combination therapy is more effective than monotherapy for CLBP,
although the adverse effects of pregabalin, mainly dizziness and headache, need to be paid attention to. 
Journal Title
Shimane journal of medical science
Volume
28
Issue
2
Start Page
59
End Page
68
ISSN
03865959
ISSN(Online)
24332410
Published Date
2012-02-01
NCID
AA00841586
Publisher Aalternative
Shimane University Faculty of Medicine
NII Type
Departmental Bulletin Paper
Format
PDF
Text Version
出版社版
OAI-PMH Set
Faculty of Medicine
Remark
http://ci.nii.ac.jp/vol_issue/nels/AA00841586_jp.html
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