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eng
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Description
Activated glial cells are capable of generating various inflammatory mediators, including cytokines, nitric oxide and reactive oxygen species. These potentially neurotoxic molecules have been suggested to play a role in the etiology and development of depression. Accumulating evidence indicates that antidepressants have inhibitory effects on inflammatory activation of glial cells and confer neuroprotection under neuropathological conditions. Such efficacy of antidepressants appears to depend on suppressing microglial production of inflammatory substances and up-regulating both astrocytic secretion of neurotrophins and astrocytic glutamine synthase, which converts neurotoxic glutamate into non-toxic glutamine. Therefore, glial cells, both as source and target of inflammatory molecules, may represent a potential promising target involved in the pathophysiology of depression. Moreover, antidepressants have the possibility to be useful treatment, not only for depression, but for a broad spectrum of neuroinflammatory and neurodegenerative disorders where the pathogenesis is associated with glial activation.
Subject
Antidepressants
anti-inflammatory effect
astrocyte
cytokine
depression
microglia
nitric oxide
reactive oxygen species
Journal Title
Current Drug Targets
Volume
14
Issue
11
Start Page
1322
End Page
1328
ISSN
1389-4501
ISSN(Online)
1873-5592
Published Date
2013
DOI
Publisher
Bentham Science Publishers
NII Type
Journal Article
Format
PDF
Text Version
出版社版
Gyoseki ID
e21724
OAI-PMH Set
Faculty of Medicine
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